HYPERBARIC OXYGEN THERAPY

Ophthalmology

Scottsdale Hyperbaric Center provides Hyperbaric Oxygen Therapy (HBOT) as an adjunctive treatment for select ophthalmologic conditions involving tissue hypoxia, ischemia, or radiation-induced injury. HBOT is recognized by the Undersea & Hyperbaric Medical Society (UHMS) for specific eye conditions and may be considered in cases where tissue oxygenation is compromised.

Common indications include:

  • Radiation-induced ocular injury – Delayed tissue damage following radiation therapy for ocular or orbital tumors

  • Acute retinal arterial occlusion – Central or branch retinal artery occlusion with acute ischemia

  • Compromised ocular grafts or reconstructive procedures – When tissue perfusion is impaired

Clinical Considerations in Ophthalmology

Ocular and periocular tissues are highly sensitive to oxygen deprivation. Compromised perfusion, post-radiation changes, or acute vascular occlusion can result in:

  • Ischemia of retinal or orbital tissues

  • Delayed healing following reconstructive or graft procedures

  • Risk of permanent tissue damage or vision loss

HBOT may be considered as an adjunctive therapy when conventional treatment alone may not fully address tissue hypoxia.

Role of Hyperbaric Oxygen Therapy

HBOT increases oxygen delivery to hypoxic ocular and periocular tissues, supporting tissue viability and recovery in compromised areas. Clinically relevant effects include:

  • Improved tissue oxygenation in ischemic retinal or orbital tissue

  • Support for post-radiation tissue repair and graft survival

  • Adjunctive management of acute vascular occlusions when initiated promptly

Treatment protocols follow UHMS clinical guidelines and are tailored individually to each patient’s condition and ophthalmologist’s plan of care.

Refer A Patient

  • Please submit the completed referral form along with supporting medical chart notes via fax to 480-590-6145.
  • For assistance with insurance coverage verification, our experienced team and insurance specialist, Isaac, is available to help determine if your patient qualifies for coverage.
  • Call our office today at 480-590-5277 to get started.

We look forward to working with you!

Research & Studies

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"Retinal artery occlusion: visual outcome after treatment with hyperbaric oxygen"

Author(s): Hayreh SS, Zimmerman MB, Kimura A, Sanon A. Retinal artery occlusion: associated systemic and ophthalmic abnormalities. Retina. 2004;24(4):491–501. PMID: 15229676.

A case series of 51 patients with central or branch retinal artery occlusion treated with HBOT demonstrated that 74 % of patients experienced improved visual acuity, with more than half improving by two lines or more on standard visual acuity charts. Improvement was observed across treatment delays ranging from less than 8 hours up to six days, highlighting the potential benefit of early intervention in ischemic retinal events.

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"Efficacy and Safety of Hyperbaric Oxygen Therapy for Retinal Artery Occlusion: A Systematic Review and Meta-Analysis"

Elfil M, Sabet H, Abbas A. Efficacy and Safety of Hyperbaric Oxygen Therapy for Retinal Artery Occlusion: A Systematic Review and Meta‑Analysis. Canadian Journal of Neurological Sciences. 2025; (published online).

A systematic review and meta‑analysis of nine studies involving 499 RAO patients (286 treated with HBOT vs. 213 controls) found that HBOT was associated with improved best‑corrected visual acuity (BCVA) compared with non‑HBOT groups (mean difference –0.63 logMAR, 95% CI –1.14 to –0.12; p = 0.01). The analysis reported a generally favorable safety profile, though study heterogeneity and limited trial sizes highlight the need for more robust prospective trials to clarify HBOT’s role in RAO management.

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